From the publisher’s rulebook

Who goes first in Potion Explosion?

Horrible Guild English rulebook, PE_Rulebook_ENG_v32

Whoever most recently prepared a drink goes first. Turns proceed clockwise.

Read the publisher’s rulebook

Rule details

That player keeps the First Player token for the whole game.

When choosing starting potions, draft the first potion clockwise from the starter, then the second potion in reverse order from the last player.

If there’s a tie

The cited starting-player instruction does not specify a tie-break. We don’t infer one.

Source & edition

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